The principle of extracting nucleic acid by magnetic bead method is based on the same principle as that of silica gel membrane centrifuge column. After the surface of Superparamagnetism nanoparticles is improved and modified by nanotechnology, Superparamagnetism silica nanobeads are prepared.

Magnetic beads can specifically recognize and efficiently bind to nucleic acid molecules at microscopic interfaces.

Using the Superparamagnetism of silica coated magnetic nanospheres, DNA and RNA can be separated from blood, animal tissue, food, pathogenic microorganisms and other samples under the action of Chaotropic salt (Guanidinium chloride, guanidine isothiocyanate, etc.) and external magnetic field, which can be used in clinical disease diagnosis, blood transfusion safety, forensic identification, food safety detection, molecular biology research and other fields.

Nucleic acid extraction by magnetic bead method has the advantages that traditional DNA extraction methods cannot match, mainly reflected in:

① It can realize automatic and mass operation. At present, there are 96 wells of automatic nucleic acid extractor, which can process 96 samples with the extraction time of one sample. It meets the requirements of biological high-throughput operation, enabling rapid and timely response to infectious Disease outbreak outbreaks. This feature makes traditional methods unmatched;

② The operation is simple and takes a short time. The entire extraction process only has four steps, and most of them can be completed within 36-40 minutes;

③ Safe and non-toxic, without the use of toxic reagents such as benzene and chloroform in traditional methods, minimizing harm to experimental operators, fully in line with modern environmental protection concepts;

④ The specific binding between magnetic beads and nucleic acids results in high purity and concentration of extracted nucleic acids.